EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier

O.V. Semyachkina-Glushkovskaya; A.S. Karavaev; M.D. Prokhorov; A.E. Runnova; E.I. Borovkova; Ishbulatov Yu.M.; A.N. Hramkov; D.D. Kulminskiy; N.I. Semenova; K.S. Sergeev; A.V. Slepnev; Sitnikova E. Yu.; M.O. Zhuravlev; I.V. Fedosov; A.A. Shirokov; I.A. Blokhina; A.I. Dubrovski; A.V. Terskov; A.P. Khorovodov; V.B. Ageev; D.A. Elovenko; A.S. Evsukova; V.V. Adushkina; V.V. Telnova; D.E. Postnov; T.U. Penzel; J.G. Kurths

Computational and Structural Biotechnology Journal (Jan 2023)

EEG biomarkers of activation of the lymphatic drainage system of the brain during sleep and opening of the blood-brain barrier

O.V. Semyachkina-Glushkovskaya,
A.S. Karavaev,
M.D. Prokhorov,
A.E. Runnova,
E.I. Borovkova,
Ishbulatov Yu.M.,
A.N. Hramkov,
D.D. Kulminskiy,
N.I. Semenova,
K.S. Sergeev,
A.V. Slepnev,
Sitnikova E. Yu.,
M.O. Zhuravlev,
I.V. Fedosov,
A.A. Shirokov,
I.A. Blokhina,
A.I. Dubrovski,
A.V. Terskov,
A.P. Khorovodov,
V.B. Ageev,
D.A. Elovenko,
A.S. Evsukova,
V.V. Adushkina,
V.V. Telnova,
D.E. Postnov,
T.U. Penzel,
J.G. Kurths

Affiliations

O.V. Semyachkina-Glushkovskaya: Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany; Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Corresponding author at: Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany.
A.S. Karavaev: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Saratov Branchof the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Zelyonaya, 38, Saratov, 410019, Russia; Saratov State Medical University, B.Kazachaya str., 112, Saratov, 410012, Russia
M.D. Prokhorov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Saratov Branchof the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Zelyonaya, 38, Saratov, 410019, Russia
A.E. Runnova: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Saratov State Medical University, B.Kazachaya str., 112, Saratov, 410012, Russia
E.I. Borovkova: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Saratov State Medical University, B.Kazachaya str., 112, Saratov, 410012, Russia
Ishbulatov Yu.M.: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Saratov Branchof the Institute of Radio Engineering and Electronics of Russian Academy of Sciences, Zelyonaya, 38, Saratov, 410019, Russia; Saratov State Medical University, B.Kazachaya str., 112, Saratov, 410012, Russia
A.N. Hramkov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
D.D. Kulminskiy: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
N.I. Semenova: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
K.S. Sergeev: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
A.V. Slepnev: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
Sitnikova E. Yu.: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Institute of Higher Nervous Activity and Neurophysiology of Russian Academy of Sciences, (IHNA&NPh RAS), 5AButlerova St., Moscow 117485, Russia
M.O. Zhuravlev: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Saratov State Medical University, B.Kazachaya str., 112, Saratov, 410012, Russia
I.V. Fedosov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
A.A. Shirokov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, ProspektEntuziastov13, Saratov 410049, Russia
I.A. Blokhina: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
A.I. Dubrovski: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
A.V. Terskov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
A.P. Khorovodov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
V.B. Ageev: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
D.A. Elovenko: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
A.S. Evsukova: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
V.V. Adushkina: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
V.V. Telnova: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
D.E. Postnov: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia
T.U. Penzel: Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany
J.G. Kurths: Physics Department, Humboldt University, Newtonstrasse 15, 12489 Berlin, Germany; Saratov State University, Astrakhanskaya str., 83, Saratov, 410012, Russia; Potsdam Institute for Climate Impact Research, Telegrafenberg A31, 14473 Potsdam, Germany

Journal volume & issue: Vol. 21
pp. 758 – 768

Abstract

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The lymphatic drainage system of the brain (LDSB) is the removal of metabolites and wastes from its tissues. A dysfunction of LDSB is an important sign of aging, brain oncology, the Alzheimer's and Parkinson's diseases. The development of new strategies for diagnosis of LDSB injuries can improve prevention of age-related cerebral amyloid angiopathy, neurodegenerative and cerebrovascular diseases. There are two conditions, such as deep sleep and opening of the blood-brain-barrier (OBBB) associated with the LDSB activation. A promising candidate for measurement of LDSB could be electroencephalography (EEG). In this pilot study on rats, we tested the hypothesis, whether deep sleep and OBBB can be an informative platform for an effective extracting of information about the LDSB functions. Using the nonlinear analysis of EEG dynamics and machine learning technology, we discovered that the LDSB activation during OBBB and sleep is associated with similar changes in the EEG θ-activity. The OBBB causes the higher LDSB activation vs. sleep that is accompanied by specific changes in the low frequency EEG activity extracted by the power spectra analysis of the EEG dynamics combined with the coherence function. Thus, our findings demonstrate a link between neural activity associated with the LDSB activation during sleep and OBBB that is an important informative platform for extraction of the EEG-biomarkers of the LDSB activity. These results open new perspectives for the development of technology for the LDSB diagnostics that would open a novel era in the prognosis of brain diseases caused by the LDSB disorders, including OBBB.

Published in Computational and Structural Biotechnology Journal

ISSN: 2001-0370 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Technology: Chemical technology: Biotechnology
Website: https://www.journals.elsevier.com/computational-and-structural-biotechnology-journal

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