Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study
Reagan Dugan,
Sreekrishna Ramakrishnapillai,
Julia St Amant,
Kori Murray,
Kevin McKlveen,
Maryam Naseri,
Kaitlyn Madden,
Lydia Bazzano,
Owen Carmichael
Affiliations
Reagan Dugan
Department of Physics & Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA, 70803, USA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA; Corresponding author at: Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
Sreekrishna Ramakrishnapillai
Department of Neurological Surgery, University of Pittsburgh, 200 Lothrop St suite b-400, Pittsburgh, PA, 15213, USA
Julia St Amant
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA
Kori Murray
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA
Kevin McKlveen
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA
Maryam Naseri
Department of Physics & Astronomy, Louisiana State University, 202 Nicholson Hall, Baton Rouge, LA, 70803, USA; Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA
Kaitlyn Madden
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA
Lydia Bazzano
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1440 Canal Street, Suite 2000, New Orleans, LA, 70112, USA
Owen Carmichael
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA
Introduction: Compartment model analysis of diffusion MRI data provides unique information on the microstructural properties of white matter. However, studies relating compartment model microstructural measures to longitudinal cardiometabolic health data are rare. Methods: 130 cognitively healthy participants in the Bogalusa Heart Study completed diffusion MRI scans. Compartment model analysis was performed, and summary metrics were measured in organized and diffuse white matter. Multiple linear regression models were used to relate the white matter microstructure metrics to demographics and cardiometabolic risk factors. Results: In both organized and diffuse white matter, age was associated with worse diffusion metrics, women had better diffusion metrics than men, and African American participants had worse diffusion metrics compared to White participants. Greater blood pressure in pre-adulthood was associated with worse diffusion metrics in midlife. Discussion: Summary metrics from compartment model analyses of diffusion MRI data were associated cardiometabolic risk factors from youth to midlife as well as demographic factors.
