Protective Effect of Fumaria parviflora Extract on Oxidative Stress and Testis Tissue Damage in Diabetic Rats

Abstract

Objectives: In this experimental research, a rat model was used to investigate the protective effect of Fumaria parviflora on oxidative stress and testis tissue damage in diabetic rats. Materials and Methods: To this end, a total of 28 male Wistar rats were utilized and randomly divided into 4 groups including control group (G1), diabetic control group (G2, DC), diabetic treated with F. parviflora extract (G3), and healthy group (G4) that received F. parviflora extract. In addition, the therapy lasted for 56 days. Then, the blood levels of some markers of oxidative stress and antioxidant enzymes, as well as sperm parameters such as concentration, motility, and morphology were assayed based on the aim of the study. Results: The histological examination showed a negative change in the DC group, and they were included in the treated groups. The plasma levels of glutathione peroxidase (GPx) and superoxide dismutase (SOD) significantly reduced in the DC group while the malondialdehyde (MDA) level enhanced the duration of diabetes. As regards the sperm parameters, the results demonstrated a significant reduction in the DC group whereas treatment with FP extract led to an increase in the quality of sperm. Conclusions: Based on the results of the present research, the F. parviflora extract has a positive role in protecting the testis tissue and sperm quality against oxidative stress in diabetic rats.

Keywords

• diabetes
• fumaria parviflora
• testis
• sperm parameters
• oxidative stress