Latent herpes virus infection in the carcinogenesis of bladder cancer

Abstract

This article discusses the basic mechanisms of latency some of the herpes viruses and the role of persistence of these viruses in oncogenesis. A statistically significant increase of the level of viral antibodies in patients with recurrent, locally advanced bladder cancer with high potential of malignancy; the statistically significant correlations between the presence of viral DNA cytomegalovirus and Epstein-Barr virus in the tumor and the level of antibodies, the stage of the process and recurrent nature of the tumor were found. The presence of viral DNA in the tumor was determined in 30% of cases.

Keywords

• bladder cancer
• epstein-barr virus
• cytomegalovirus
• herpes viruses type 1 and 2