Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

• Sandra Almeida,
• Zhijun Zhang,
• Giovanni Coppola,
• Wenjie Mao,
• Kensuke Futai,
• Anna Karydas,
• Michael D. Geschwind,
• M. Carmela Tartaglia,
• Fuying Gao,
• Davide Gianni,
• Miguel Sena-Esteves,
• Daniel H. Geschwind,
• Bruce L. Miller,
• Robert V. Farese, Jr.,
• Fen-Biao Gao

Affiliations

Sandra Almeida

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA

Zhijun Zhang

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA

Giovanni Coppola

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

Wenjie Mao

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA

Kensuke Futai

Brudnick Neuropsychiatric Research Institute, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA

Anna Karydas

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA

Michael D. Geschwind

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA

M. Carmela Tartaglia

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA

Fuying Gao

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

Davide Gianni

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA

Miguel Sena-Esteves

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA

Daniel H. Geschwind

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

Bruce L. Miller

Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143, USA

Robert V. Farese, Jr.

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA

Fen-Biao Gao

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA