Nature Communications (Sep 2020)
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically
- Enkhtsetseg Munkhbaatar,
- Michelle Dietzen,
- Deepti Agrawal,
- Martina Anton,
- Moritz Jesinghaus,
- Melanie Boxberg,
- Nicole Pfarr,
- Pidassa Bidola,
- Sebastian Uhrig,
- Ulrike Höckendorf,
- Anna-Lena Meinhardt,
- Adam Wahida,
- Irina Heid,
- Rickmer Braren,
- Ritu Mishra,
- Arne Warth,
- Thomas Muley,
- Patrina S. P. Poh,
- Xin Wang,
- Stefan Fröhling,
- Katja Steiger,
- Julia Slotta-Huspenina,
- Martijn van Griensven,
- Franz Pfeiffer,
- Sebastian Lange,
- Roland Rad,
- Magda Spella,
- Georgios T. Stathopoulos,
- Jürgen Ruland,
- Florian Bassermann,
- Wilko Weichert,
- Andreas Strasser,
- Caterina Branca,
- Mathias Heikenwalder,
- Charles Swanton,
- Nicholas McGranahan,
- Philipp J. Jost
Affiliations
- Enkhtsetseg Munkhbaatar
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Michelle Dietzen
- Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute
- Deepti Agrawal
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Martina Anton
- Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich
- Moritz Jesinghaus
- Institute of Pathology, Technical University of Munich
- Melanie Boxberg
- Institute of Pathology, Technical University of Munich
- Nicole Pfarr
- Institute of Pathology, Technical University of Munich
- Pidassa Bidola
- Chair of Biomedical Physics, Department of Physics & Munich School of Bioengineering, Technical University of Munich
- Sebastian Uhrig
- Division of Applied Bioinformatics, German Cancer Research Center
- Ulrike Höckendorf
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Anna-Lena Meinhardt
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Adam Wahida
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Irina Heid
- Department of diagnostic and interventional radiology, Klinikum rechts der Isar, Technical University of Munich
- Rickmer Braren
- Department of diagnostic and interventional radiology, Klinikum rechts der Isar, Technical University of Munich
- Ritu Mishra
- Center for Translational Cancer Research (TranslaTUM), Technical University of Munich
- Arne Warth
- Institute of Pathology, University Hospital Heidelberg
- Thomas Muley
- Translational Research Unit, Thoraxklinik at Heidelberg University
- Patrina S. P. Poh
- Experimental Trauma Surgery, Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich
- Xin Wang
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Stefan Fröhling
- Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ)
- Katja Steiger
- Institute of Pathology, Technical University of Munich
- Julia Slotta-Huspenina
- Institute of Pathology, Technical University of Munich
- Martijn van Griensven
- Department cBITE, MERLN Institute, Maastricht University
- Franz Pfeiffer
- Chair of Biomedical Physics, Department of Physics & Munich School of Bioengineering, Technical University of Munich
- Sebastian Lange
- Center for Translational Cancer Research (TranslaTUM), Technical University of Munich
- Roland Rad
- Center for Translational Cancer Research (TranslaTUM), Technical University of Munich
- Magda Spella
- Laboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras
- Georgios T. Stathopoulos
- Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), Helmholtz Center Munich for Environmental Health, Member of the German Center for Lung Research (DZL)
- Jürgen Ruland
- German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Florian Bassermann
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Wilko Weichert
- Institute of Pathology, Technical University of Munich
- Andreas Strasser
- The Walter and Eliza Hall Institute of Medical Research
- Caterina Branca
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- Mathias Heikenwalder
- Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ)
- Charles Swanton
- Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute
- Nicholas McGranahan
- Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute
- Philipp J. Jost
- Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich
- DOI
- https://doi.org/10.1038/s41467-020-18372-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Cancer cells frequently harbour genetic aberrations that protect them from programmed cell death. Here, the authors show in non-small cell lung cancer that the anti-apoptotic gene MCL-1 is subject to copy number gains and that deletion of MCL-1 reduces tumour formation.
