Molecules
(Oct 2019)
Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol
Naoko Takenaga,
Toshitaka Shoji,
Takayuki Menjo,
Akiko Hirai,
Shohei Ueda,
Kotaro Kikushima,
Tomonori Hanasaki,
Toshifumi Dohi
Affiliations
Naoko Takenaga
Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan
Toshitaka Shoji
College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
Takayuki Menjo
Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
Akiko Hirai
College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
Shohei Ueda
Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
Kotaro Kikushima
College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
Tomonori Hanasaki
Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
Toshifumi Dohi
College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525–8577, Japan
DOI
https://doi.org/10.3390/molecules24213812
Journal volume & issue
Vol. 24,
no. 21
Abstract
Read online
Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues.
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