Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

Joshua C. Brown; Amber Petersen; Ling Zhong; Miranda L. Himelright; Jessica A. Murphy; Randall S. Walikonis; Nashaat Z. Gerges

doi:10.1038/ncomms11080

Nature Communications (Mar 2016)

Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression

Joshua C. Brown,
Amber Petersen,
Ling Zhong,
Miranda L. Himelright,
Jessica A. Murphy,
Randall S. Walikonis,
Nashaat Z. Gerges

Affiliations

Joshua C. Brown: Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin
Amber Petersen: Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin
Ling Zhong: Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin
Miranda L. Himelright: Department of Physiology and Neurobiology, University of Connecticut
Jessica A. Murphy: Department of Physiology and Neurobiology, University of Connecticut
Randall S. Walikonis: Department of Physiology and Neurobiology, University of Connecticut
Nashaat Z. Gerges: Department of Cell Biology, Neurobiology and Anatomy, The Medical College of Wisconsin

DOI: https://doi.org/10.1038/ncomms11080
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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BRAG1 mutations are linked to synaptic deficits and X-chromosome linked intellectual disability. Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via Arf-GEF activity and PDZ interactions, and is required for maintaining AMPAR-mediated synaptic transmission.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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