Pharmaceutics
(Nov 2020)
The Aerogen<sup>®</sup> Solo Is an Alternative to the Small Particle Aerosol Generator (SPAG-2) for Administration of Inhaled Ribavirin
Ronald H. Dallas,
Jason K. Rains,
Keith Wilder,
William Humphrey,
Shane J. Cross,
Saad Ghafoor,
Jessica N. Brazelton de Cardenas,
Randall T. Hayden,
Diego R. Hijano
Affiliations
Ronald H. Dallas
Department of Infectious Diseases, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Jason K. Rains
Department of Critical Care and Pulmonary Medicine, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Keith Wilder
Department of Critical Care and Pulmonary Medicine, St. Jude Children Research Hospital, Memphis, TN 38105, USA
William Humphrey
Department of Pharmaceutical Sciences, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Shane J. Cross
Department of Pharmaceutical Sciences, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Saad Ghafoor
Department of Critical Care and Pulmonary Medicine, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Jessica N. Brazelton de Cardenas
Department of Pathology, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Randall T. Hayden
Department of Pathology, St. Jude Children Research Hospital, Memphis, TN 38105, USA
Diego R. Hijano
Department of Infectious Diseases, St. Jude Children Research Hospital, Memphis, TN 38105, USA
DOI
https://doi.org/10.3390/pharmaceutics12121163
Journal volume & issue
Vol. 12,
no. 12
p.
1163
Abstract
Read online
Respiratory syncytial virus (RSV) is associated with adverse outcomes among immunocompromised patients. Inhaled ribavirin has been shown to improve mortality rates. The Small-Particle Aerosol Generator delivery system (SPAG-2) is the only FDA-cleared device to deliver inhaled ribavirin. However, it is difficult to set up and maintain. We developed a method for delivery of this medication using the vibrating mesh nebulizer (Aerogen®). We did not observe any adverse events with this method.
Keywords
WeChat QR code
Close