Nature Communications (Mar 2023)
Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes
- Lingling Li,
- Dongxian Jiang,
- Hui Liu,
- Chunmei Guo,
- Rui Zhao,
- Qiao Zhang,
- Chen Xu,
- Zhaoyu Qin,
- Jinwen Feng,
- Yang Liu,
- Haixing Wang,
- Weijie Chen,
- Xue Zhang,
- Bin Li,
- Lin Bai,
- Sha Tian,
- Subei Tan,
- Zixiang Yu,
- Lingli Chen,
- Jie Huang,
- Jian-Yuan Zhao,
- Yingyong Hou,
- Chen Ding
Affiliations
- Lingling Li
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Dongxian Jiang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Hui Liu
- State Key Laboratory Cell Differentiation and Regulation, Overseas Expertise Introduction Center for Discipline Innovation of Pulmonary Fibrosis, (111 Project), College of Life Science, Henan Normal University
- Chunmei Guo
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Rui Zhao
- Institute for Development and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua HospitalShanghai Jiao Tong University School of Medicine
- Qiao Zhang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Chen Xu
- Department of Pathology, Zhongshan Hospital, Fudan University
- Zhaoyu Qin
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Jinwen Feng
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Yang Liu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Haixing Wang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Weijie Chen
- Department of Pathology, Zhongshan Hospital, Fudan University
- Xue Zhang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Bin Li
- Department of Pathology, Zhongshan Hospital, Fudan University
- Lin Bai
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Sha Tian
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Subei Tan
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Zixiang Yu
- Department of Pathology, Zhongshan Hospital, Fudan University
- Lingli Chen
- Department of Pathology, Zhongshan Hospital, Fudan University
- Jie Huang
- Department of Pathology, Zhongshan Hospital, Fudan University
- Jian-Yuan Zhao
- Institute for Development and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua HospitalShanghai Jiao Tong University School of Medicine
- Yingyong Hou
- Department of Pathology, Zhongshan Hospital, Fudan University
- Chen Ding
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- DOI
- https://doi.org/10.1038/s41467-023-37221-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 24
Abstract
Duodenal cancer (DC) has complex subtypes and undergoes complicated morphological changes throughout progression, so understanding the molecular basis is crucial. Here, the authors perform a proteogenomics analysis of 156 DCs, revealing molecular subtypes as well as the roles of smoking, AARS1 and PARP1.
