The presence of extra chromosomes leads to genomic instability

Verena Passerini; Efrat Ozeri-Galai; Mirjam S. de Pagter; Neysan Donnelly; Sarah Schmalbrock; Wigard P. Kloosterman; Batsheva Kerem; Zuzana Storchová

doi:10.1038/ncomms10754

Nature Communications (Feb 2016)

The presence of extra chromosomes leads to genomic instability

Verena Passerini,
Efrat Ozeri-Galai,
Mirjam S. de Pagter,
Neysan Donnelly,
Sarah Schmalbrock,
Wigard P. Kloosterman,
Batsheva Kerem,
Zuzana Storchová

Affiliations

Verena Passerini: Max Planck Institute of Biochemistry, Am Klopferspitz 18
Efrat Ozeri-Galai: Department of Genetics, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus, Givat-Ram
Mirjam S. de Pagter: Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100
Neysan Donnelly: Max Planck Institute of Biochemistry, Am Klopferspitz 18
Sarah Schmalbrock: Max Planck Institute of Biochemistry, Am Klopferspitz 18
Wigard P. Kloosterman: Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Universiteitsweg 100
Batsheva Kerem: Department of Genetics, The Alexander Silberman Institute of Life Sciences, Edmond J. Safra Campus, Givat-Ram
Zuzana Storchová: Max Planck Institute of Biochemistry, Am Klopferspitz 18

DOI: https://doi.org/10.1038/ncomms10754
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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