Nature Communications (Jan 2021)
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape
- Zhiqiang Ku,
- Xuping Xie,
- Edgar Davidson,
- Xiaohua Ye,
- Hang Su,
- Vineet D. Menachery,
- Yize Li,
- Zihao Yuan,
- Xianwen Zhang,
- Antonio E. Muruato,
- Ariadna Grinyo i Escuer,
- Breanna Tyrell,
- Kyle Doolan,
- Benjamin J. Doranz,
- Daniel Wrapp,
- Paul F. Bates,
- Jason S. McLellan,
- Susan R. Weiss,
- Ningyan Zhang,
- Pei-Yong Shi,
- Zhiqiang An
Affiliations
- Zhiqiang Ku
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Xuping Xie
- Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch
- Edgar Davidson
- Integral Molecular, Philadelphia
- Xiaohua Ye
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Hang Su
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Vineet D. Menachery
- Department of Microbiology & Immunology, University of Texas Medical Branch
- Yize Li
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
- Zihao Yuan
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Xianwen Zhang
- Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch
- Antonio E. Muruato
- Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch
- Ariadna Grinyo i Escuer
- Integral Molecular, Philadelphia
- Breanna Tyrell
- Integral Molecular, Philadelphia
- Kyle Doolan
- Integral Molecular, Philadelphia
- Benjamin J. Doranz
- Integral Molecular, Philadelphia
- Daniel Wrapp
- Department of Molecular Biosciences, University of Texas at Austin
- Paul F. Bates
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
- Jason S. McLellan
- Department of Molecular Biosciences, University of Texas at Austin
- Susan R. Weiss
- Department of Microbiology, Perelman School of Medicine, University of Pennsylvania
- Ningyan Zhang
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Pei-Yong Shi
- Department of Biochemistry and Molecular Biology, Institute for Human Infection and Immunity, Sealy Institute for Vaccine Sciences, Sealy Center for Structural Biology & Molecular Biophysics, Department of Pharmacology & Toxicology, University of Texas Medical Branch
- Zhiqiang An
- Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- DOI
- https://doi.org/10.1038/s41467-020-20789-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. Here, Ku et al., identify SARS-CoV-2 neutralizing antibodies from a phage library and identify an antibody combination that prevents viral escape and protects mice from viral challenge.
