Nutrition Journal (Aug 2011)

The role of soluble fiber intake in patients under highly effective lipid-lowering therapy

  • Rezende Vinicius M,
  • Moreno Ronilson A,
  • Borges Ney C,
  • Helfenstein Tatiana,
  • Moreira Flávio T,
  • Kasmas Soraia H,
  • Fonseca Francisco A,
  • Ramos Silvia C,
  • Silva Fernanda C,
  • Izar Maria C

DOI
https://doi.org/10.1186/1475-2891-10-80
Journal volume & issue
Vol. 10, no. 1
p. 80

Abstract

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Abstract Background It has been demonstrated that statins can increase intestinal sterol absorption. Augments in phytosterolemia seems related to cardiovascular disease. Objective We examined the role of soluble fiber intake in endogenous cholesterol synthesis and in sterol absorption among subjects under highly effective lipid-lowering therapy. Design In an open label, randomized, parallel-design study with blinded endpoints, subjects with primary hypercholesterolemia (n = 116) were assigned to receive during 12 weeks, a daily dose of 25 g of fiber (corresponding to 6 g of soluble fibers) plus rosuvastatin 40 mg (n = 28), rosuvastatin 40 mg alone (n = 30), sinvastatin 40 mg plus ezetimibe 10 mg plus 25 g of fiber (n = 28), or sinvastatin 40 mg plus ezetimibe 10 mg (n = 30) alone. Results The four assigned therapies produced similar changes in total cholesterol, LDL-cholesterol, and triglycerides (p Conclusion Among subjects treated with highly effective lipid-lowering therapy, the intake of 25 g of fibers added favorable effects, mainly by reducing phytosterolemia. Additional benefits include improvement in blood glucose and anthropometric parameters.

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