COMPLEX EFFECTS OF SALMOZAN MEDICINE AND PROBIOТIC BACTERIA OF LACTOBACILLUS GENUS ON NATURAL RESISTANCE AND ADAPTIVE IMMUNIТY OF EXPERIMENTAL ANIМALS

Abstract

Results of study of immunoprotective properties of medicine Salmozan and its combined effect with probiotic bacteria of genus Lactobacillus оп natural resistance and parameters of adaptive immunity of experimental animals аге presented. Salmozan stimulates production of IL-1α, IL-12, TNFα in peritoneal macrophages, production of MIF in реуеr patch and spleen cells and, thus, activates Th1 cells and cytotoxic T cells. Bacteria of Lactobacillus genus enhance modulating effects of Salmozan оn cellular immune reactions. Results of the experiments carried out provide the basis for conclusion abont stimulation of anti-infection and anticancer immunity bу Salmozan which саn bе used fог immunoprophylaxis and соrrеction of cellular immune reactions bу means of probiotic therapy.

Keywords

• immunomodulation
• lactobacilli
• cell-mediated immune response