In Vitro and In Vivo Antitumor Activity of Indolo[2,3-<i>b</i>] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Najla Altwaijry; Samah El-Ghlban; Ibrahim E.-T. El Sayed; Mohamed El-Bahnsawye; Asmaa I. Bayomi; Rehab M. Samaka; Elkhabiry Shaban; Elshaymaa I. Elmongy; Thanaa A. El-Masry; Hytham M. A. Ahmed; Nashwah G. M. Attallah

doi:10.3390/molecules26030754

Molecules (Feb 2021)

In Vitro and In Vivo Antitumor Activity of Indolo[2,3-<i>b</i>] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Najla Altwaijry,
Samah El-Ghlban,
Ibrahim E.-T. El Sayed,
Mohamed El-Bahnsawye,
Asmaa I. Bayomi,
Rehab M. Samaka,
Elkhabiry Shaban,
Elshaymaa I. Elmongy,
Thanaa A. El-Masry,
Hytham M. A. Ahmed,
Nashwah G. M. Attallah

Affiliations

Najla Altwaijry: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Samah El-Ghlban: Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Ibrahim E.-T. El Sayed: Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Mohamed El-Bahnsawye: Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Asmaa I. Bayomi: Department of Zoology, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Rehab M. Samaka: Department of Pathology, Faculty of Medicine, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Elkhabiry Shaban: Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza P.O. Box 12622, Egypt
Elshaymaa I. Elmongy: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Thanaa A. El-Masry: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Hytham M. A. Ahmed: Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Shebin El Koom P.O. Box 32511, Menoufia, Egypt
Nashwah G. M. Attallah: Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia

DOI: https://doi.org/10.3390/molecules26030754
Journal volume & issue: Vol. 26, no. 3
p. 754

Abstract

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Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). The analogs showed stronger cytotoxic activity against EAC cells than the reference drug. The in vivo evaluation of the target compounds against EAC-induced solid tumor in the female albino Swiss mice revealed a remarkable decrease in the tumor volume (TV) and hepatic lipid peroxidation. A noticeable increase of both superoxide dismutase (SOD) and catalase (CAT) levels was reported (p p < 0.001) with the elevation of the responsiveness of lymphocytes to phytohemagglutinin (PHA). These results indicate that these naturally-based neocryptolepine alkaloids exhibit marked antitumor activity in vivo and represent an important lead in the development of natural-based anticancer drugs.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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