In Vitro and In Vivo Antitumor Activity of Indolo[2,3-<i>b</i>] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid
Najla Altwaijry,
Samah El-Ghlban,
Ibrahim E.-T. El Sayed,
Mohamed El-Bahnsawye,
Asmaa I. Bayomi,
Rehab M. Samaka,
Elkhabiry Shaban,
Elshaymaa I. Elmongy,
Thanaa A. El-Masry,
Hytham M. A. Ahmed,
Nashwah G. M. Attallah
Affiliations
Najla Altwaijry
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Samah El-Ghlban
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Ibrahim E.-T. El Sayed
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Mohamed El-Bahnsawye
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Asmaa I. Bayomi
Department of Zoology, Faculty of Science, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Rehab M. Samaka
Department of Pathology, Faculty of Medicine, Menoufia University, Shebin El Koom P.O. Box 32511, Egypt
Elkhabiry Shaban
Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, 33 El Bohouth St., Dokki, Giza P.O. Box 12622, Egypt
Elshaymaa I. Elmongy
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Thanaa A. El-Masry
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Hytham M. A. Ahmed
Pharmaceutical Analysis Department, Faculty of Pharmacy, Menoufia University, Shebin El Koom P.O. Box 32511, Menoufia, Egypt
Nashwah G. M. Attallah
Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah bint Abdulrahman University, Riyadh P.O. Box 84428, Saudi Arabia
Neocryptolepine (5-methyl-5H-indolo[2,3-b] quinoline) analogs were synthesized and evaluated in vitro and in vivo for their effect versus Ehrlich ascites carcinoma (EAC). The analogs showed stronger cytotoxic activity against EAC cells than the reference drug. The in vivo evaluation of the target compounds against EAC-induced solid tumor in the female albino Swiss mice revealed a remarkable decrease in the tumor volume (TV) and hepatic lipid peroxidation. A noticeable increase of both superoxide dismutase (SOD) and catalase (CAT) levels was reported (p p < 0.001) with the elevation of the responsiveness of lymphocytes to phytohemagglutinin (PHA). These results indicate that these naturally-based neocryptolepine alkaloids exhibit marked antitumor activity in vivo and represent an important lead in the development of natural-based anticancer drugs.
