Communications Biology (Jan 2022)
SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB
- Christopher J. Neufeldt,
- Berati Cerikan,
- Mirko Cortese,
- Jamie Frankish,
- Ji-Young Lee,
- Agnieszka Plociennikowska,
- Florian Heigwer,
- Vibhu Prasad,
- Sebastian Joecks,
- Sandy S. Burkart,
- David Y. Zander,
- Baskaran Subramanian,
- Rayomand Gimi,
- Seetharamaiyer Padmanabhan,
- Radhakrishnan Iyer,
- Mathieu Gendarme,
- Bachir El Debs,
- Niels Halama,
- Uta Merle,
- Michael Boutros,
- Marco Binder,
- Ralf Bartenschlager
Affiliations
- Christopher J. Neufeldt
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Berati Cerikan
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Mirko Cortese
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Jamie Frankish
- BioMed X Institute, BioMed X GmbH
- Ji-Young Lee
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Agnieszka Plociennikowska
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Florian Heigwer
- Division of Signaling and Functional Genomics, German Cancer Research Center, and Department of Cell and Molecular Biology, Heidelberg University, Medical Faculty Mannheim
- Vibhu Prasad
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Sebastian Joecks
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Sandy S. Burkart
- Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response”, Division Virus-Associated Carcinogenesis, German Cancer Research Center
- David Y. Zander
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- Baskaran Subramanian
- Spring Bank Pharmaceuticals, Inc.
- Rayomand Gimi
- Spring Bank Pharmaceuticals, Inc.
- Seetharamaiyer Padmanabhan
- Spring Bank Pharmaceuticals, Inc.
- Radhakrishnan Iyer
- Spring Bank Pharmaceuticals, Inc.
- Mathieu Gendarme
- BioMed X Institute, BioMed X GmbH
- Bachir El Debs
- BioMed X Institute, BioMed X GmbH
- Niels Halama
- Division of Translational Immunotherapy, German Cancer Research Center (DKFZ)
- Uta Merle
- Department of Internal Medicine IV, University Hospital Heidelberg
- Michael Boutros
- Division of Signaling and Functional Genomics, German Cancer Research Center, and Department of Cell and Molecular Biology, Heidelberg University, Medical Faculty Mannheim
- Marco Binder
- Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response”, Division Virus-Associated Carcinogenesis, German Cancer Research Center
- Ralf Bartenschlager
- Department of Infectious Diseases, Molecular Virology, Heidelberg University
- DOI
- https://doi.org/10.1038/s42003-021-02983-5
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Neufeldt et al. evaluate transcriptional and cytokine secretion profiles of cells and patient sera following SARS-CoV-2 infection and detect distinct upregulation of inflammatory cytokines. They also demonstrate that this upregulation is mediated by cGAS-STING and NF-κB signalling, which could provide a potential avenue for the development of future therapies against SARS-CoV-2.
