Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala

Yan Lin; Linghong Miao; Xiaoqin Li; Linjie Qian; Qiaoqiao Mu; Bo Liu; Xianping Ge; Xiangjun Leng

Aquaculture Reports (Dec 2023)

Effects of ferulic acid on the growth performance, physiological and biochemical functions, and hepato-intestinal health of blunt snout bream, Megalobrama amblycephala

Yan Lin,
Linghong Miao,
Xiaoqin Li,
Linjie Qian,
Qiaoqiao Mu,
Bo Liu,
Xianping Ge,
Xiangjun Leng

Affiliations

Yan Lin: National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition (CREEFN) of the Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China
Linghong Miao: Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Xiaoqin Li: National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition (CREEFN) of the Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai 201306, China
Linjie Qian: Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Qiaoqiao Mu: Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Bo Liu: Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China
Xianping Ge: Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Key Laboratory of Aquatic Animal Nutrition and Health, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China; Correspondence to: Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, No. 9 Shanshui East Road, Wuxi, Jiangsu 214081, China.
Xiangjun Leng: National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Centre for Research on Environmental Ecology and Fish Nutrition (CREEFN) of the Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Collaborative Innovation for Aquatic Animal Genetics and Breeding, Shanghai Ocean University, Shanghai 201306, China; Correspondence to: Shanghai Ocean University, Hucheng Ring road 999, Lingang New City, Shanghai 201306, China.

Journal volume & issue: Vol. 33
p. 101879

Abstract

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To investigate the impact of dietary inclusion of ferulic acid (FA) on growth performance, physiological and biochemical functions and hepato-intestinal health, three iso-nitrogenous and iso-lipidic diets supplemented with 0 mg/kg, 100 mg/kg, and 200 mg/kg FA were fed to Megalobrama amblycephala (9.75 ± 0.04 g) for 8 weeks. The growth performance, physiological and biochemical parameters, antioxidant capacity and the expression of genes were assessed on 4th and 8th week. The results indicated that 100 mg/kg FA inclusion significantly enhanced the weight gain rate (on week 4 and 8), feed intake (on 4th week), protein efficiency ratio (on week 8) and condition factor (on week 4) (P < 0.05). In plasma biochemical index, dietary FA significantly reduced the contents of alanine aminotransferase, glucose and lactate dehydrogenase on 8th week (P < 0.05). In the antioxidant capacity, dietary FA decreased the malondialdehyde (MDA) content in hepatopancreas and intestine (P < 0.05), while increased the activities of total superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and glutathione S-transferase (P < 0.05), and the best effects were observed at 100 mg/kg FA inclusion on 8th week. On 8th week, the supplementation of 100 mg/kg FA down-regulated the expression levels of inflammation-related genes (interleukin-6, interleukin-1β (hepatopancreas only), nuclear factor-κB), pro-apoptotic gene caspase-8 and endoplasmic reticulum stress-related genes (X-box-binding protein 1 S, protein kinase R-like ER kinase, inositol requiring enzyme 1, C/EBP homologous protein, immunoglobulin binding protein (hepatopancreas only), activated transcription factor 6α, activated transcription factor 4) (P < 0.05), while the anti-apoptotic gene B lymphoblastoma-2 was significantly up-regulated (P < 0.05). In conclusion, FA enhanced the growth performance, antioxidant and anti-inflammatory properties, reduced apoptosis level, and maintained the hepato-intestinal endoplasmic reticulum homeostasis. The FA inclusion was suggested at 100 mg/kg.

Published in Aquaculture Reports

ISSN: 2352-5134 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Agriculture: Aquaculture. Fisheries. Angling
Website: http://www.journals.elsevier.com/aquaculture-reports/

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