Cancer Management and Research (Oct 2021)
Analysis of the Effect of Trastuzumab Combined with Docetaxel on Serum Tumor Markers in the Treatment of HER-2 Positive Breast Cancer and Factors Influencing Therapeutic Efficacy
Abstract
Qi-Zhu Feng,1– 3 Xian-Zhi Chen,2 Jie Sun,4 Man-Man Lu,5 Yong Wang,6 Qi Wang,4 Chao Zhang1,3 1Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui, People’s Republic of China; 2Department of Breast Surgery, First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People’s Hospital), Huainan, 232007, Anhui, People’s Republic of China; 3School of Continuing Education, Anhui Medical University, Hefei, 230032, Anhui, People’s Republic of China; 4Department of General Surgery, First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People’s Hospital), Huainan, 232007, Anhui, People’s Republic of China; 5Department of Laboratory Medicine, First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People’s Hospital), Huainan, 232007, Anhui, People’s Republic of China; 6Department of Medical Oncology, First Affiliated Hospital of Anhui University of Science and Technology (Huainan First People’s Hospital), Huainan, 232007, Anhui, People’s Republic of ChinaCorrespondence: Chao ZhangDepartment of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, 230032, Anhui, People’s Republic of ChinaTel +86-13956053990Email [email protected]: To explore the influence of trastuzumab (TZ) combined with docetaxel (DTX) on serum tumor markers (TMs) in the treatment of human epidermal growth factor receptor 2-positive (HER-2+) breast cancer (BC) and to analyze the factors influencing therapeutic efficacy.Methods: Ninety-six patients with HER-2+ BC treated in the First Affiliated Hospital of Anhui University Of Science and Technology from January 2019 to December 2020 were selected. According to different treatment plans, the patients were divided into two arms with 48 cases each. The control group (CG) was treated with DTX, and the research group (RG) was given TZ combined with DTX (TZ+DTX). The two arms were compared regarding the following aspects: curative effects, adverse reaction, alterations of TMs and inflammatory factors (IFs), and quality of life. Logistic regression analysis was performed to analyze the factors affecting the efficacy of patients.Results: After treatment, the TMs carcinoembryonic antigen (CEA), carbohydrate antigen (CA)125 and CA15-3 were significantly lower in RG compared with CG. The levels of IFs C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were also lower in CG. The overall response rate and the Karnofsky performance status (KPS) score were significantly higher in RG. No evident difference was observed in the total incidence of adverse reactions between the two arms. The high expression of CEA, CA125 and CA15-3 as well as DTX monotherapy increased the risk of adverse prognosis.Conclusion: TZ+DTX can effectively improve the clinical efficacy of HER-2+ BC patients and reduce their levels of serum TMs and IFs.Keywords: trastuzumab combined with docetaxel, HER-2+ breast cancer, tumor markers, analysis of therapeutic factors
