Molecules (Mar 2010)

Evaluation of the Antiradical Activity of Schisandra Chinensis Lignans Using Different Experimental Models

  • Karel Šmejkal,
  • Tereza Šlapetová,
  • Pavel Krmenčík,
  • Renata Kubínová,
  • Pavel Suchý,
  • Stefano Dall´Acqua,
  • Gabbriella Innocenti,
  • Ján Vančo,
  • Karolína Kalvarová,
  • Margita Dvorská,
  • Jiří Slanina,
  • Eva Kramářová,
  • Jan Muselík,
  • Milan Žemlička

DOI
https://doi.org/10.3390/molecules15031223
Journal volume & issue
Vol. 15, no. 3
pp. 1223 – 1231

Abstract

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The in vitro antiradical activity of Schisandra chinensis lignans was investigated using DPPH, ABTS+, Fenton reaction inhibition and tyrosine-nitration inhibition assays, as were the in vivo antidiabetic activities of selected lignans in an animal model of alloxan-induced diabetes. Different degrees of antiradical activity were found, depending upon the structural parameters of the tested compounds. Unfortunately, the compounds showed no antidiabetic activity in concentration range tested.

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