Амбулаторная хирургия (Jun 2017)
Can amtolmetin guacil be useful in surgical practice?
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the main classes of analgesics and indispensable component of an integrated program of pain management in anesthetic, surgical and traumatology patients. But the use of NSAIDs may be complicated by the development of a whole range of adverse reactions in the gastrointestinal tract (GIT), the cardiovascular system and kidneys and increase the risk of postoperative hemorrhage. Family of NSAIDs has a lot of drugs but none of them can be considered ideal in terms of efficacy and safety. Therefore, the development of a new representative of this drug group - amtolmetin guacil - is of great interest to practitioners. This drug has the characteristics of the pharmacological action defining its gastroprotective potential (primarily due to the increase in the concentration of nitric oxide in the mucosa), and the ability to greatly reduce the negative effects on the gastrointestinal tract. Although amtolmetin guaci is mainly used for the relief of pain in diseases of joints and spine (osteoarthritis, back pain, rheumatoid arthritis, etc.), it can be used for pain management in surgical patients.
