Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network

Chengshun Li; Xiaolan Li; Ziping Jiang; Dongxu Wang; Liqun Sun; Jiaqi Li; Yang Han

doi:10.3389/fonc.2022.842790

Frontiers in Oncology (Mar 2022)

Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network

Chengshun Li,
Xiaolan Li,
Ziping Jiang,
Dongxu Wang,
Liqun Sun,
Jiaqi Li,
Yang Han

Affiliations

Chengshun Li: Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China
Xiaolan Li: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China
Ziping Jiang: Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China
Dongxu Wang: Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China
Liqun Sun: Department of Pediatrics, First Hospital of Jilin University, Changchun, China
Jiaqi Li: Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China
Yang Han: Laboratory Animal Center, College of Animal Science, Jilin University, Changchun, China

DOI: https://doi.org/10.3389/fonc.2022.842790
Journal volume & issue: Vol. 12

Abstract

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Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (ceRNA) network is a complex post-transcriptional regulatory mechanism in cells, in which coding and non-coding RNAs competitively bind miRNAs to regulate messenger RNAs (mRNAs). This review focused on the role of the ceRNA network in the treatment of cancer by flavonoids.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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