Nornicotine-typed insecticides: The potential insecticides with strong activity against Diaphorina citri

Pengfei Hu; Xiaoping Ye; Xiaoping Song; Mingxin Yang; Yunsheng Zhong; Yijing Cen; Yanxin Zhang; Yiming Song; Qingchao Liu

Advanced Agrochem (Jun 2023)

Nornicotine-typed insecticides: The potential insecticides with strong activity against Diaphorina citri

Pengfei Hu,
Xiaoping Ye,
Xiaoping Song,
Mingxin Yang,
Yunsheng Zhong,
Yijing Cen,
Yanxin Zhang,
Yiming Song,
Qingchao Liu

Affiliations

Pengfei Hu: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China
Xiaoping Ye: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China
Xiaoping Song: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China
Mingxin Yang: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China
Yunsheng Zhong: Laboratory of Insect Ecology, South China Agricultural University, Guangzhou, China
Yijing Cen: Laboratory of Insect Ecology, South China Agricultural University, Guangzhou, China
Yanxin Zhang: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China; Glycobiology and Glycotechnology Research Center, College of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, 710069, China; College of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an, 710069, China; Corresponding author. College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China.
Yiming Song: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China; Corresponding author.
Qingchao Liu: College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, 710069, China; Corresponding author.

Journal volume & issue: Vol. 2, no. 2
pp. 180 – 184

Abstract

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Nicotine and nornicotine-typed compounds are well-known for its potential as insecticide. Some researches have shown that nicotine was highly toxic to Diaphorina citri Kuwayama, an invasive and fast spreading pest. Here we report the effects of nornicotine-typed insecticide against D. citri. Novel compounds A1-A8, B1–B28, C1–C18 and D1-D12 were synthesized by reported procedure. And bioassays indicated that some of these compounds exhibited good effects against D. citri. Compounds B2, B3, B8, B12, B13, B22, C5, C7, D5, and D9 exhibited the mortality up to 100% within 120 h in 50 mg/L. And further data shows that A2-5, A7, B1, B8, B20 and B22 showed rapid insecticidal activities against D. citri in 24 h with the low LC50 (LC50 < 50 mg/L in 24 h, and LC50 < 30 mg/L in 72 h). Nornicotine-typed derivatives exhibited activity against D. citri, and B8 and B22 exhibited the best insecticidal activity with an LC50 of 18.0 ± 1.0, 18.2 ± 0.9 mg/L in 24 h, which had the lower cost than nicotine and showed the potential as powerful insecticides.

Published in Advanced Agrochem

ISSN: 2773-2371 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Agriculture: Agriculture (General); Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.keaipublishing.com/en/journals/advanced-agrochem/

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