Nature Communications (Nov 2021)
Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages
- Xionghui Ding,
- Hiroto Kambara,
- Rongxia Guo,
- Apurva Kanneganti,
- Maikel Acosta-Zaldívar,
- Jiajia Li,
- Fei Liu,
- Ting Bei,
- Wanjun Qi,
- Xuemei Xie,
- Wenli Han,
- Ningning Liu,
- Cunling Zhang,
- Xiaoyu Zhang,
- Hongbo Yu,
- Li Zhao,
- Fengxia Ma,
- Julia R. Köhler,
- Hongbo R. Luo
Affiliations
- Xionghui Ding
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Hiroto Kambara
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Rongxia Guo
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Apurva Kanneganti
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Maikel Acosta-Zaldívar
- Division of Infectious Diseases, Boston Children’s Hospital/Harvard Medical School
- Jiajia Li
- State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Chinese Academy of Medical Sciences & Peking Union Medical College
- Fei Liu
- State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Chinese Academy of Medical Sciences & Peking Union Medical College
- Ting Bei
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Wanjun Qi
- Division of Infectious Diseases, Boston Children’s Hospital/Harvard Medical School
- Xuemei Xie
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Wenli Han
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Ningning Liu
- Division of Infectious Diseases, Boston Children’s Hospital/Harvard Medical School
- Cunling Zhang
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Xiaoyu Zhang
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Hongbo Yu
- VA Boston Healthcare System, Department of Pathology and Laboratory Medicine
- Li Zhao
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- Fengxia Ma
- State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, CAMS Key laboratory for prevention and control of hematological disease treatment related infection, Chinese Academy of Medical Sciences & Peking Union Medical College
- Julia R. Köhler
- Division of Infectious Diseases, Boston Children’s Hospital/Harvard Medical School
- Hongbo R. Luo
- Department of Pathology, Dana-Farber/Harvard Cancer Center, Harvard Medical School; Department of Laboratory Medicine, Boston Children’s Hospital
- DOI
- https://doi.org/10.1038/s41467-021-27034-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 24
Abstract
Inflammasome signalling has been shown to protect Candida albicans during infection and as such limits inflammasome inhibitors in this context. Here the authors implicate Gasdermin D in C.ablicans immune evasion and suggests its targeting therapeutically.
