Normal pressure hydrocephalus and cerebral amyloid angiopathy: a set of diseases or the unity of pathogenesis?

Abstract

Idiopathic normal pressure hydrocephalus (NPH) is cerebral ventriculomegaly characterized by a wide range of controversial issues related to the prevalence of the disease, the mechanisms of its development, and nosological independence. Developing in old age, NTH is often concurrent with other neurodegenerative or cerebrovascular diseases, posing certain diagnostic difficulties. The paper describes a clinical case of a patient initially diagnosed with NTH, followed by amyloid angiopathy signs detected during magnetic resonance imaging after bypass surgery. It discusses the diagnostic features of NTH and amyloid angiopathy and the possible common mechanisms of these diseases.

Keywords

• normal pressure hydrocephalus
• cerebral amyloid angiopathy
• alzheimer's disease
• cerebrospinal fluid