Nature Communications (Jul 2016)
Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis
- Blerida Banushi,
- Federico Forneris,
- Anna Straatman-Iwanowska,
- Adam Strange,
- Anne-Marie Lyne,
- Clare Rogerson,
- Jemima J. Burden,
- Wendy E. Heywood,
- Joanna Hanley,
- Ivan Doykov,
- Kornelis R. Straatman,
- Holly Smith,
- Danai Bem,
- Janos Kriston-Vizi,
- Gema Ariceta,
- Maija Risteli,
- Chunguang Wang,
- Rosalyn E. Ardill,
- Marcin Zaniew,
- Julita Latka-Grot,
- Simon N. Waddington,
- S. J. Howe,
- Francesco Ferraro,
- Asllan Gjinovci,
- Scott Lawrence,
- Mark Marsh,
- Mark Girolami,
- Laurent Bozec,
- Kevin Mills,
- Paul Gissen
Affiliations
- Blerida Banushi
- MRC Laboratory for Molecular Cell Biology, University College London
- Federico Forneris
- Department of Biology and Biotechnology, The Armenise-Harvard Laboratory of Structural Biology, University of Pavia
- Anna Straatman-Iwanowska
- MRC Laboratory for Molecular Cell Biology, University College London
- Adam Strange
- Eastman Dental Institute, University College London
- Anne-Marie Lyne
- Department of Statistical Science, University College London
- Clare Rogerson
- MRC Laboratory for Molecular Cell Biology, University College London
- Jemima J. Burden
- MRC Laboratory for Molecular Cell Biology, University College London
- Wendy E. Heywood
- Institute of Child Health, University College London
- Joanna Hanley
- Institute of Child Health, University College London
- Ivan Doykov
- Institute of Child Health, University College London
- Kornelis R. Straatman
- Centre for Core Biotechnology Services, University of Leicester
- Holly Smith
- MRC Laboratory for Molecular Cell Biology, University College London
- Danai Bem
- Centre for Cardiovascular Sciences, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham
- Janos Kriston-Vizi
- MRC Laboratory for Molecular Cell Biology, University College London
- Gema Ariceta
- Department of Pediatric Nephrology, University Hospital Vall d'Hebron, Universitat Autonoma Barcelona
- Maija Risteli
- Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Chunguang Wang
- Medical Research Center Oulu, Oulu University Hospital, University of Oulu
- Rosalyn E. Ardill
- Royal Hospital for Sick Children
- Marcin Zaniew
- Children's Hospital
- Julita Latka-Grot
- Children's Memorial Health Institute
- Simon N. Waddington
- Institute for Women’s Health, University College London
- S. J. Howe
- Institute for Women’s Health, University College London
- Francesco Ferraro
- MRC Laboratory for Molecular Cell Biology, University College London
- Asllan Gjinovci
- MRC Laboratory for Molecular Cell Biology, University College London
- Scott Lawrence
- MRC Laboratory for Molecular Cell Biology, University College London
- Mark Marsh
- MRC Laboratory for Molecular Cell Biology, University College London
- Mark Girolami
- Department of Statistics, University of Warwick
- Laurent Bozec
- Eastman Dental Institute, University College London
- Kevin Mills
- Institute of Child Health, University College London
- Paul Gissen
- MRC Laboratory for Molecular Cell Biology, University College London
- DOI
- https://doi.org/10.1038/ncomms12111
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Lysine hydroxylation of procollagen precursors by LH3 is required for collagen fibril crosslinking and stabilization. Here the authors show that the trafficking protein VIPAR is required for correct sorting of LH3 into post-Golgi collagen carriers and for correct collagen modification and structure.
