Chirality imprinting and direct asymmetric reaction screening using a stereodynamic Brønsted/Lewis acid receptor

Abstract

Determining results of asymmetric reactions can take long periods of time and consume large amounts of organic solvents during work-up and analysis. Here, the authors report a bifunctional organic probe that can bind to chiral hydroxyacids, and provide yield, enantiomeric excess and absolute configuration even with crude mixtures.