Ocular coherence tomography image data of the retinal laminar structure in a mouse model of oxygen-induced retinopathy
Wendy A. Dailey,
Kimberly A. Drenser,
Sui Chien Wong,
Mei Cheng,
Joseph Vercellone,
Kevin K. Roumayah,
Erin V. Feeney,
Mrinalini Deshpande,
Alvaro E. Guzman,
Michael Trese,
Kenneth P. Mitton
Affiliations
Wendy A. Dailey
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States
Kimberly A. Drenser
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States; Associated Retinal Consultants, Novi, MI, United States
Sui Chien Wong
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States
Mei Cheng
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States
Joseph Vercellone
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States
Kevin K. Roumayah
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States
Erin V. Feeney
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States
Mrinalini Deshpande
Control of Gene Expression Laboratory, Eye Research Institute, Oakland University, United States
Alvaro E. Guzman
Control of Gene Expression Laboratory, Eye Research Institute, Oakland University, United States
Michael Trese
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States; Associated Retinal Consultants, Novi, MI, United States
Kenneth P. Mitton
Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States; Control of Gene Expression Laboratory, Eye Research Institute, Oakland University, United States; Corresponding author at: Pediatric Retinal Research Laboratory, Eye Research Institute, Oakland University, Rochester, MI 48309, United States.
The data presented in this article are related to the research paper entitled âNorrin treatment improves ganglion cell survival in an oxygen-induced model of retinal ischemiaâ (Dailey et al., 2017) [1] This article describes treatment with the human Norrin protein, an atypical Wnt-protein, to improve the survival of retinal ganglion cells in a murine model of Oxygen-Induced Retinopathy (OIR). That study utilized Optical coherence tomography (OCT) to visualize retinal layers at high resolution in vivo, and to quantify changes to nerve fiber layer thickness. Organization of the laminar structure of other retinal layers in this model in vivo, were not known because of uncertainties regarding potential artifacts during the processing of tissue for traditional histology. The OCT image data provided here shows researchers the retinal laminar structural features that exist in vivo in this popular mouse OIR model. Traditional H&E stained retinal tissue sections are also provided here for comparison. Keywords: Ocular coherence tomography, Retina, Oxygen-induced retinopathy, Mouse retina, Retinal imaging
