Microwave-Assisted Sol–Gel Preparation of the Nanostructured Magnetic System for Solid-Phase Synthesis
Daniela Istrati,
Alina Moroșan,
Raluca Stan,
Bogdan Ștefan Vasile,
Gabriel Vasilievici,
Ovidiu Oprea,
Georgiana Dolete,
Bogdan Purcăreanu,
Dan Eduard Mihaiescu
Affiliations
Daniela Istrati
Department of Organic Chemistry “Costin Nenitescu”, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
Alina Moroșan
Department of Organic Chemistry “Costin Nenitescu”, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
Raluca Stan
Department of Organic Chemistry “Costin Nenitescu”, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
Bogdan Ștefan Vasile
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
Gabriel Vasilievici
INCDCP-ICECHIM, 202 Spl. Independentei, 011061 Bucharest, Romania
Ovidiu Oprea
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
Georgiana Dolete
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
Bogdan Purcăreanu
S.C. BIOTEHNOS S.A., Gorunului Rue, No. 3–5, 075100 Ilfov, Romania
Dan Eduard Mihaiescu
Department of Organic Chemistry “Costin Nenitescu”, Faculty of Applied Chemistry and Materials Science, University POLITEHNICA of Bucharest, 011061 Bucharest, Romania
This work describes a new synthesis method for core–shell magnetite nanoparticles with a secondary silica shell, functionalized with a linker system (Fe3O4-PABA-SiO2-linker) using a microwave-assisted heating technique. The functionalized solid nanomaterial was used for the nanophase synthesis of peptides (Fmoc route) as a solid support. The co-precipitation method was selected to obtain magnetite nanoparticles and sol–gel technique for silica coating using a microwave-assisted (MW) procedure. The magnetic properties of the nanoparticle core offer the advantage of a quick and easy alternative for the magnetic separation of the product from the reaction mixture, facilitating all the intermediary washing and separation operations. The intermediate and final materials were analyzed by advanced characterization methods. The effectiveness of the nanophase peptide synthesis using this nanostructured material as solid support was demonstrated for a short peptide sequence.
