Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Natalie K. Lee; Ka Wai Fok; Amanda White; Nicole H. Wilson; Conor J. O’Leary; Hayley L. Cox; Magdalene Michael; Alpha S. Yap; Helen M. Cooper

doi:10.1038/ncomms11082

Nature Communications (Mar 2016)

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Natalie K. Lee,
Ka Wai Fok,
Amanda White,
Nicole H. Wilson,
Conor J. O’Leary,
Hayley L. Cox,
Magdalene Michael,
Alpha S. Yap,
Helen M. Cooper

Affiliations

Natalie K. Lee: Queensland Brain Institute, The University of Queensland
Ka Wai Fok: Queensland Brain Institute, The University of Queensland
Amanda White: Queensland Brain Institute, The University of Queensland
Nicole H. Wilson: Queensland Brain Institute, The University of Queensland
Conor J. O’Leary: Queensland Brain Institute, The University of Queensland
Hayley L. Cox: Queensland Brain Institute, The University of Queensland
Magdalene Michael: Institute for Molecular Bioscience, The University of Queensland
Alpha S. Yap: Institute for Molecular Bioscience, The University of Queensland
Helen M. Cooper: Queensland Brain Institute, The University of Queensland

DOI: https://doi.org/10.1038/ncomms11082
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The stability of epithelial adherens junctions depends on tension generated by actomyosin contractility. Here Lee et al. describe a novel role for the axon guidance receptor Neogenin in maintaining junctional stability by recruiting actin nucleation machinery to adherens junctions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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