Nature Communications (Jun 2021)
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
- Stephanie P. Totten,
- Young Kyuen Im,
- Eduardo Cepeda Cañedo,
- Ouafa Najyb,
- Alice Nguyen,
- Steven Hébert,
- Ryuhjin Ahn,
- Kyle Lewis,
- Benjamin Lebeau,
- Rachel La Selva,
- Valérie Sabourin,
- Constanza Martínez,
- Paul Savage,
- Hellen Kuasne,
- Daina Avizonis,
- Nancy Santos Martínez,
- Catherine Chabot,
- Adriana Aguilar-Mahecha,
- Marie-Line Goulet,
- Matthew Dankner,
- Michael Witcher,
- Kevin Petrecca,
- Mark Basik,
- Michael Pollak,
- Ivan Topisirovic,
- Rongtuan Lin,
- Peter M. Siegel,
- Claudia L. Kleinman,
- Morag Park,
- Julie St-Pierre,
- Josie Ursini-Siegel
Affiliations
- Stephanie P. Totten
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Young Kyuen Im
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Eduardo Cepeda Cañedo
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Ouafa Najyb
- Department of Biochemistry, McGill University
- Alice Nguyen
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Steven Hébert
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Ryuhjin Ahn
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Kyle Lewis
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Benjamin Lebeau
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Rachel La Selva
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Valérie Sabourin
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Constanza Martínez
- Goodman Cancer Research Centre, McGill University
- Paul Savage
- Goodman Cancer Research Centre, McGill University
- Hellen Kuasne
- Goodman Cancer Research Centre, McGill University
- Daina Avizonis
- Goodman Cancer Research Centre, McGill University
- Nancy Santos Martínez
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Catherine Chabot
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Adriana Aguilar-Mahecha
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Marie-Line Goulet
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Matthew Dankner
- Division of Experimental Medicine, McGill University
- Michael Witcher
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Kevin Petrecca
- Department of Neurology and Neurosurgery, McGill University
- Mark Basik
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Michael Pollak
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Ivan Topisirovic
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Rongtuan Lin
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Peter M. Siegel
- Division of Experimental Medicine, McGill University
- Claudia L. Kleinman
- Lady Davis Institute for Medical Research, Jewish General Hospital
- Morag Park
- Department of Biochemistry, McGill University
- Julie St-Pierre
- Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa
- Josie Ursini-Siegel
- Lady Davis Institute for Medical Research, Jewish General Hospital
- DOI
- https://doi.org/10.1038/s41467-021-23396-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Complex I inhibition induces oxidative stress leading to cancer cell cytotoxicity. Here, the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor phenformin cytotoxicity through STAT1-mediated downregulation of the reactive oxygen species scavenger NQO1.
