Jornal Brasileiro de Psiquiatria (Oct 2024)

Accuracy of the revised Addenbrooke Cognitive Examination (ACE-R) in older adults with low education and mild cognitive impairment: results of a cross-sectional study in two metropolitan areas of Northeast Brazil

  • Jhule Silva Passinho,
  • José Wagner Leonel Tavares-Júnior,
  • Felipe Kenji Sudo,
  • Lays Bittencourt,
  • Candida Helena Lopes Alves,
  • José Ibiapina Siqueira-Neto,
  • Pedro Braga Neto,
  • Gilberto Sousa Alves

DOI
https://doi.org/10.1590/0047-2085-2023-0035
Journal volume & issue
Vol. 73, no. 2

Abstract

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ABSTRACT Objective To determine the diagnostic accuracy of the Addenbrooke’s Cognitive Examination (ACE-R) for older adults with low education, without dementia, in two capitals in northeastern Brazil, compared to subjects with MCI. Methods 100 participants were collected from a previous neurological and psychiatric evaluation and were subsequently subjected to the ACE-R. Among them, 18 subjects with amnestic mild cognitive impairment (aMCI), 22 with non-amnestic mild cognitive impairment (naMCI), and 60 healthy controls. Results Optimal ACE-R accuracy yielded excellent values for the comparison between controls and naMCI [Area Under the Curve (AUC) = 0.919)] and controls and aMCI (AUC= 0.921); conversely, very fair accuracy was reported for the comparison between aMCI and naMCI (AUC= 0.578). Conclusions These findings support establishing reliable cutoff scores for cognitive assessment of elderlies with low schooling and cognitive decline, not dementia, taking into consideration ecological and regional variables.

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