Molecules
(Mar 2020)
Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral <i>Briareum excavatum</i> (Briareidae)
Thanh-Hao Huynh,
Lee-Shing Fang,
Yu-Hsin Chen,
Bo-Rong Peng,
You-Ying Chen,
Li-Guo Zheng,
Yu-Jen Wu,
Zhi-Hong Wen,
Jih-Jung Chen,
Tzu-Chi Lin,
Ping-Jyun Sung
Affiliations
Thanh-Hao Huynh
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
Lee-Shing Fang
Center for Environmental Toxin and Emerging-Contaminant Research, Cheng Shiu University, Kaohsiung 83347, Taiwan
Yu-Hsin Chen
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
Bo-Rong Peng
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
You-Ying Chen
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
Li-Guo Zheng
National Museum of Marine Biology and Aquarium, Pingtung 94450, Taiwan
Yu-Jen Wu
Department of Nursing, Meiho University, Pingtung 91202, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
Jih-Jung Chen
Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, Taipei 11221, Taiwan
Tzu-Chi Lin
Department of Emergency Medicine, Antai Medical Care Corporation Antai Tian-Sheng Memorial Hospital, Pingtung 92842, Taiwan
Ping-Jyun Sung
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, Taiwan
DOI
https://doi.org/10.3390/molecules25061405
Journal volume & issue
Vol. 25,
no. 6
Abstract
Read online
Five 8,17-epoxybriaranes, including three new compounds—briarenols I−K (1−3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1−3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.
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