If the current policy explores the utilization of active ingredients in use quickly and to the maximum, the same does not occur with the ban on the registration of products highly dangerous to both health and the environment. The current policy does not aim at reducing pesticide toxicity and ecotoxicity, required to reduce environmental contamination and human exposure. To this end, it is essential to adjust scientific evaluation parameters concerning lower concentration tolerance limits to modernity standards, in addition to banning products for which there is scientific evidence of carcinogenic, teratogenic, and mutagenic actions. In ecotoxicology, reducing the applicable concentration limits is paramount for preserving bees, birds, and other forms of domestic and wildlife. When evaluating active ingredients, it is imperative to prioritize more biodegradable molecules with low potential for environmental mobilization through volatilization and leaching, preserving both air and water quality. Another goal, among others, is a program for the generalized reduction of successfully implemented in several countries. Brazil, a tropical agriculture leader, should stand out by incorporating sustainability while preserving both health and the environment.