Stereoselective alkoxycarbonylation of unactivated C(sp3)–H bonds with alkyl chloroformates via Pd(II)/Pd(IV) catalysis

Abstract

Carbonylation of unactivated C-H bonds is typically carried out on primary C-H sites using gaseous carbon monoxide. Here the authors report a palladium cataylsed alkoxycarbonylation process using alkyl chloroformates that functionalises more challenging unactivated secondary C-H sites.