Use of alternative cerebrospinal fluid‐based biomarkers to help diagnose Xpert‐negative tuberculous meningitis: A case report

Abstract

Abstract The widely used Xpert MTB/RIF assay, limited by its suboptimal sensitivity, does not perform well as a rule‐out test for tuberculous meningitis. Alternative CSF‐based biomarkers can help determine the microbial etiology of clinical meningitis when standard diagnostic modalities fail.

Keywords

• adenosine deaminase
• CSF‐based biomarkers
• negative Xpert assay
• tuberculous meningitis