The use of extracorporeal etiotropic therapy in complex treatment of patients with chronic urinogenital trichomoniasis

Abstract

Address deficiencies in the methods of treatment of patients with chronic trichomoniasis. The cause of ineffective therapy may be low concentration antitrichomonal drugs in foci of chronic inflammation in the urinary organs, because of microcirculatory disorders and the development of scarring. The difficulty in achieving therapeutic concentrations of chemotherapeutic drugs in the affected tissues due to the laws of their pharma-cokinetics and the lack of effective methods for their directed transport. With a view to readjustment of the genitourinary system of trichomonas invasion, we used the method of directed transport of metronidazole in autoleukocyts, which was previously activated helium-neon laser, which created in inflammatory foci of urinary tract maximally effective concentration of the chemotherapy. The introduction of chemotherapeutic drugs in the patients was carried out by alternative drug-induced plasma exchange. The data of comparative evaluation of the effectiveness of traditional and developed ways to treat showed that the drug-induced plasma exchange shortened at 2 times the basic terms of the normalization of the clinical manifestations of disease. Due to the directed transport of metronidazole in inflammation was achieved by greater efficiency in treatment of trichomoniasis than using the traditional treatment. Foci of invasion sanation was observed immediately after the application of this method of therapy. High antitrichomonal efficiency observed in the late period of observation for patients.

Keywords

• trichomonas vaginalis
• urogenital trichomoniasis
• therapy
• drug-induced plasma exchange