Expression of CD34, DOG1, S100 in CD117-negative and CD117-positive gastrointestinal stromal tumors with different potential of malignancy and clinical, morphological features

Abstract

Diagnosis verification of gastrointestinal stromal tumor (GIST) requires thorough differential diagnosis and determination of malignancy potential. Aim. In order to evaluate the relationship between clinical (patient age, localization of the primary tumor), morphological (histological type) and immunohistochemical (CD117status, Ki-67 index) data in GIST samples of 43 patient we studied the expression of markers DOG1, CD34, S100. Methods and results. It was established, that S100-positive (+) cases are found in less than 5% of GIST, and CD34+ and DOG1+ in 81.4% and 86.6% respectively. Reliable relationship between characters of expression of CD34, DOG1 and clinical and morphological data was not detected (p> 0.05). The portion of cases of CD34-, DOG1- (50%) is dominant in groups with high Ki-67, and portion of CD34+, DOG1+ (40%, 40.9% respectively) - with low, but this relationship was not statistically confirmed (p > 0,05).

Keywords

• Stomасh Diseases
• Neoplasms
• Immunohistochemistry