Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation

Lin Yang; Zhenxing Ren; Shenyu Yan; Ling Zhao; Jie Liu; Lijun Zhao; Zhen Li; Shanyu Ye; Aijun Liu; Xichan Li; Jiasong Guo; Wei Zhao; Weihong Kuang; Helu Liu; Dongfeng Chen

doi:10.1038/s42003-022-03420-x

Communications Biology (May 2022)

Nsun4 and Mettl3 mediated translational reprogramming of Sox9 promotes BMSC chondrogenic differentiation

Lin Yang,
Zhenxing Ren,
Shenyu Yan,
Ling Zhao,
Jie Liu,
Lijun Zhao,
Zhen Li,
Shanyu Ye,
Aijun Liu,
Xichan Li,
Jiasong Guo,
Wei Zhao,
Weihong Kuang,
Helu Liu,
Dongfeng Chen

Affiliations

Lin Yang: Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Zhenxing Ren: Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
Shenyu Yan: Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, The University of Hong Kong
Ling Zhao: Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine
Jie Liu: Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Lijun Zhao: Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Zhen Li: Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Shanyu Ye: Department of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine
Aijun Liu: Department of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine
Xichan Li: School of Chinese Herbal Medicine, Guangzhou University of Chinese Medicine
Jiasong Guo: Department of Histology and Embryology, Southern Medical University
Wei Zhao: RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Weihong Kuang: Guangdong Key Laboratory for Research and Development of Natural Drugs, Key Laboratory of Research and Development of New Medical Materials of Guangdong Medical University, School of Pharmacy, Guangdong Medical University
Helu Liu: Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Dongfeng Chen: Department of Anatomy, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine

DOI: https://doi.org/10.1038/s42003-022-03420-x
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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Nsun4-mediated m5C and Mettl3-mediated m6A are found to be required for Sox9-regulated chondrogenic differentiation, whereby Nsun4 and Mettl3 interact with each other and recruit Ythdf2 and eEF1a-1 to form a complex at the 3’UTR of Sox9.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal