Mechanism of myocardial mitochondrial injury in sepsis

Abstract

Sepsis and infectious shock remain the leading causes of death in critically ill patients. Despite the adoption of various treatment strategies to date, the outcomeshave been suboptimal. Sepsis-induced myocardial dysfunction (SIMD) is a common complication of severe sepsis. It is one of the leading causes of death. Therefore, further understanding of SIMD is very important for the treatment of sepsis. Mitochondria, as the main sites of energy metabolism of cardiomyocytes, play an important role in structural abnormalities and dysfunction. Mitochondrial dysfunction mainly includes oxidative stress, mitochondrial uncoupling, disturbance of mitochondrial quality control system, Ca2+ overload and altered mitochondrial membrane permeability.

Keywords

• sepsis
• mitochondrion
• cardiac dysfunction
• oxidative stress
• calcium overload
• mitochondrial quality control