Pro-inflammatory cytokines induce c-fos expression followed by IL-6 release in human 
airway smooth muscle cells

Affiliations

Sue McKay: Department of Pharmacology, Erasmus University Medical Center (EMCR), Dr. Molewaterplein 50, 3015 GE, The Netherlands
Mechteld M. Grootte Bromhaar: Department of Pharmacology, Erasmus University Medical Center (EMCR), Dr. Molewaterplein 50, 3015 GE, The Netherlands
Johan C. de Jongste: Department of Paediatrics-Respiratory Medicine, Sophia Children's Hospital, Rotterdam, The Netherlands
Henk C. Hoogsteden: Department of Pulmonary-Medicine, Erasmus University Medical Centre Rotterdam, The Netherlands
Pramod R. Saxena: Department of Pharmacology, Erasmus University Medical Center (EMCR), Dr. Molewaterplein 50, 3015 GE, The Netherlands
Hari S. Sharma: Department of Pharmacology, Erasmus University Medical Center (EMCR), Dr. Molewaterplein 50, 3015 GE, The Netherlands

Abstract

Background: Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation.