Disturbance of oxidant/antioxidant balance, acute phase response and high mobility group box–1 protein in acute undifferentiated diarrhea in crossbred piglets

Abstract

The objective of the present study was to investigate the status of high mobility group box–1 (HMGB1) protein, oxidative stress and acute phase proteins in natural cases of acute undifferentiated diarrhoea in piglets aged 1–15 days old. The study was conducted on 30 crossbred (Landrace × indigenous) piglets; fifteen suffering from acute enteritis (group 1) and fifteen healthy piglets as control (group 2). The diarrhoea was diagnosed on the basis of clinical symptoms. From the results of the study, it is concluded that HMGB1 protein, markers of oxidative stress and acute phase proteins might play important roles in the pathophysiology of piglet diarrhoea and that these may be targets for supportive therapy.

Keywords

• Ceruloplasmin
• Haptoglobin
• HMBG1
• Oxidative stress
• Piglet diarrhoea