Trophic Factor Withdrawal Induces a Novel Pathway: p38 MAPK Activates NHE1 Resulting in Intracellular Alkalinization, an Early Step in Apoptosis

• Annette R. Khaled,
• Kyungjae Kim,
• Kathrin Muegge,
• Craig Thompson,
• Larry Fliegel,
• Scott K. Durum

Affiliations

Annette R. Khaled

Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD, 21702, USA

Kyungjae Kim

Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD, 21702, USA

Kathrin Muegge

SAIC, National Cancer Institute, Frederick, MD, 21702, USA

Craig Thompson

University of Pennsylvania, Philadelphia, PA, 19104, USA

Larry Fliegel

University of Alberta, Edmonton, Alberta, Canada

Scott K. Durum

Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD, 21702, USA