Development and Validation of an LC–MS-Based Quantification Assay for New Therapeutic Antibodies: Application to a Novel Therapy against Herpes Simplex Virus

• Margaux Fresnais,
• Rémi Longuespée,
• Max Sauter,
• Torsten Schaller,
• Michaela Arndt,
• Jürgen Krauss,
• Antje Blank,
• Walter E. Haefeli,
• Jürgen Burhenne

Affiliations

Margaux Fresnais

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany

Rémi Longuespée

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany

Max Sauter

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany

Torsten Schaller

Heidelberg ImmunoTherapeutics GmbH, Heidelberg, Germany

Michaela Arndt

Heidelberg ImmunoTherapeutics GmbH, Heidelberg, Germany

Jürgen Krauss

Department of Medical Oncology, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany

Antje Blank

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany

Walter E. Haefeli

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany

Jürgen Burhenne

Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Heidelberg, Germany