Мать и дитя в Кузбассе (Feb 2022)

SPERM DNA FRAGMENTATION IN INFERTILE MEN OF KUZBASS

  • Алексей Геннадьевич Тришкин,
  • Антон Игоревич Лесников,
  • Лилия Владиславовна Курганова,
  • Константин Александрович Луговой,
  • Алексей Дмитриевич Бушмакин,
  • Галина Павловна Зуева,
  • Алексей Андреевич Шмелев,
  • Светлана Ивановна Елгина,
  • Вадим Гельевич Мозес,
  • Елена Владимировна Рудаева,
  • Кира Борисовна Мозес

Journal volume & issue
Vol. 23, no. 1
pp. 36 – 40

Abstract

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The standard method for diagnosing male infertility involves a spermogram, which does not always give a complete picture of male fertility. One additional method for assessing ejaculate is the sperm DNA fragmentation test (SDF), which determines the integrity of the paternal genome. Objective – to study sperm DNA fragmentation in Kuzbass men and evaluate potential relationships between the level of DNA damage, clinical parameters, and spermogram parameters. Results. The results of the study demonstrate a significant statistical relationship between DNA fragmentation of spermatozoa with progressive motility (p < 0.049), age (p < 0.040) and body mass index (BMI) (p < 0.028). Also, %SDF is significantly higher in asthenozoospermic patients (p < 0.004) than in normal patients. A correlation with %SDF was observed in terms of general (r = -0.265) and progressive (r = -0.254) mobility, viability (r = -0.205), as well as clinical parameters, age (r = 0.331) and BMI (r = 0.279). Conclusions. The study found a relationship between DNA fragmentation and motility, viability of spermatozoa, age of patients and their BMI.

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