The action of ionizing irradiation alone or in combination with cisplatin on malignant cells: Investigations in vitro

Abstract

The paper gives a brief review of the literature data based on in vitro investigations of cytotoxic action of cisplatin and irradiation, applied alone or in combination, to carcinoma cell lines and fresh tumor explants. Presented data, observed in the light of data obtained in clinics, indicate that in vivo some additional tumor destructive activity might be induced by applied therapy. Therefore examinations of the antitumor effect of some treatment need to be more complex and must include determination of the effects of applied therapy on set of parameters, which control tumor growth in vivo.

Keywords

• combined modality therapy
• tumor cells
• cultured
• cisplatin
• radiation
• ionizing