A case of junctional epidermolysis bullosa intermediate with collagen XVII deficiency treated with dupilumab

Li Zhang; Shangshang Wang; Qinyi Chen; Leihong Xiang

doi:10.1080/09546634.2023.2253943

Journal of Dermatological Treatment (Dec 2023)

A case of junctional epidermolysis bullosa intermediate with collagen XVII deficiency treated with dupilumab

Li Zhang,
Shangshang Wang,
Qinyi Chen,
Leihong Xiang

Affiliations

Li Zhang: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P.R. China
Shangshang Wang: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P.R. China
Qinyi Chen: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P.R. China
Leihong Xiang: Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, P.R. China

DOI: https://doi.org/10.1080/09546634.2023.2253943
Journal volume & issue: Vol. 34, no. 1

Abstract

Read online

AbstractInherited epidermolysis bullosa is a heterogeneous group of hereditary skin diseases characterized by skin (mucosa) fragility, which leads to blistering. Junctional epidermolysis bullosa is associated with mutations in genes expressing proteins of the dermo-epidermal junction. Dupilumab, an antibody that directly targets interleukin (IL)-4 receptor alpha, may be an effective treatment for dystrophic epidermolysis bullosa. We describe a case of junctional epidermolysis bullosa that improved with dupilumab.

Published in Journal of Dermatological Treatment

ISSN: 0954-6634 (Print); 1471-1753 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Dermatology
Website: https://www.tandfonline.com/journals/ijdt20

About the journal

Abstract

Keywords