The Combination of Lewis Acid with <i>N</i>-Heterocyclic Carbene (NHC) Catalysis

Abstract

In the last ten years, the combination of Lewis acid with N-heterocyclic carbene (NHC) catalysis has emerged as a powerful strategy in a variety of important asymmetric synthesis, due to the ready availability of starting materials, operational simplicity and mild reaction conditions. Recent findings illustrate that Lewis acid could largely enhance the efficiency and enantioselectivity, reverse the diastereoselectivity, and even influence the pathway of the same reaction partners. Herein, this review aims to reveal the recent advances in NHC-Lewis acid synergistically promoted enantioselective reactions for the expeditious assembly of versatile biologically important chiral pharmaceuticals and natural products.

Keywords

• <i>n</i>-heterocyclic carbenes (nhc)
• lewis acid
• cooperative catalysis
• asymmetric synthesis
• umpolung