Frontiers in Endocrinology (Feb 2023)
The relationship between fat distribution in central region and comorbidities in obese people: Based on NHANES 2011–2018
- Chen-An Liu,
- Chen-An Liu,
- Chen-An Liu,
- Chen-An Liu,
- Chen-An Liu,
- Tong Liu,
- Tong Liu,
- Tong Liu,
- Tong Liu,
- Tong Liu,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Guo-Tian Ruan,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Yi-Zhong Ge,
- Meng-Meng Song,
- Meng-Meng Song,
- Meng-Meng Song,
- Meng-Meng Song,
- Meng-Meng Song,
- Hai-Lun Xie,
- Hai-Lun Xie,
- Hai-Lun Xie,
- Hai-Lun Xie,
- Hai-Lun Xie,
- Shi-Qi Lin,
- Shi-Qi Lin,
- Shi-Qi Lin,
- Shi-Qi Lin,
- Shi-Qi Lin,
- Li Deng,
- Li Deng,
- Li Deng,
- Li Deng,
- Li Deng,
- He-Yang Zhang,
- He-Yang Zhang,
- He-Yang Zhang,
- He-Yang Zhang,
- He-Yang Zhang,
- Qi Zhang,
- Qi Zhang,
- Han-Ping Shi,
- Han-Ping Shi,
- Han-Ping Shi,
- Han-Ping Shi,
- Han-Ping Shi
Affiliations
- Chen-An Liu
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Chen-An Liu
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Chen-An Liu
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Chen-An Liu
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Chen-An Liu
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Tong Liu
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Tong Liu
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Tong Liu
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Tong Liu
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Tong Liu
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Guo-Tian Ruan
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Guo-Tian Ruan
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Yi-Zhong Ge
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Yi-Zhong Ge
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Meng-Meng Song
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Meng-Meng Song
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Meng-Meng Song
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Meng-Meng Song
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Meng-Meng Song
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Hai-Lun Xie
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Hai-Lun Xie
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Hai-Lun Xie
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Hai-Lun Xie
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Hai-Lun Xie
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Shi-Qi Lin
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Shi-Qi Lin
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Shi-Qi Lin
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Shi-Qi Lin
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Shi-Qi Lin
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Li Deng
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Li Deng
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Li Deng
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Li Deng
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Li Deng
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- He-Yang Zhang
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- He-Yang Zhang
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- He-Yang Zhang
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- He-Yang Zhang
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- He-Yang Zhang
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Qi Zhang
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- Qi Zhang
- Department of Colorectal Surgery, The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China
- Han-Ping Shi
- Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Han-Ping Shi
- Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, China
- Han-Ping Shi
- National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
- Han-Ping Shi
- Key Laboratory of Cancer Food for Special Medical Purposes (FSMP) for State Market Regulation, Beijing, China
- Han-Ping Shi
- Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition, Capital Medical University, Beijing, China
- DOI
- https://doi.org/10.3389/fendo.2023.1114963
- Journal volume & issue
-
Vol. 14
Abstract
BackgroundCentral obesity is closely related to comorbidity, while the relationship between fat accumulation pattern and abnormal distribution in different parts of the central region of obese people and comorbidity is not clear. This study aimed to explore the relationship between fat distribution in central region and comorbidity among obese participants.MethodsWe used observational data of NHANES 2011–2018 to identify 12 obesity-related comorbidities in 7 categories based on questionnaire responses from participants. Fat distribution is expressed by fat ratio, including Android, Gynoid, visceral, subcutaneous, visceral/subcutaneous (V/S), and total abdominal fat ratio. Logistic regression analysis were utilized to elucidate the association between fat distribution and comorbidity.ResultsThe comorbidity rate was about 54.1% among 4899 obese participants (weighted 60,180,984, 41.35 ± 11.16 years, 57.5% female). There were differences in fat distribution across the sexes and ages. Among men, Android fat ratio (OR, 4.21, 95% CI, 1.54–11.50, Ptrend=0.007), visceral fat ratio (OR, 2.16, 95% CI, 1.42–3.29, Ptrend<0.001) and V/S (OR, 2.07, 95% CI, 1.43–2.99, Ptrend<0.001) were independent risk factors for comorbidity. Among these, there was a “J” shape correlation between Android fat ratio and comorbidity risk, while visceral fat ratio and V/S exhibited linear relationships with comorbidity risk. The Gynoid fat ratio (OR, 0.87, 95%CI, 0.80–0.95, Ptrend=0.001) and subcutaneous fat ratio (OR, 0.81, 95%CI, 0.67–0.98, Ptrend=0.016) both performed a protective role in the risk of comorbidity. In women, Android fat ratio (OR, 4.65, 95% CI, 2.11–10.24, Ptrend=0.020), visceral fat ratio (OR, 1.83, 95% CI, 1.31–2.56, Ptrend=0.001), and V/S (OR, 1.80, 95% CI, 1.32–2.45, Ptrend=0.020) were also independent risk factors for comorbidity, with a dose-response relationship similar to that of men. Only the Gynoid fat ratio (OR, 0.93, 95% CI, 0.87–0.99, Ptrend=0.016) had a protective effect on female comorbidity. This association was also seen in obese participants of different age groups, comorbidity numbers, and comorbidity types, although it was more statistically significant in older, complex comorbidity, cardiovascular, cerebrovascular, and metabolic diseases.ConclusionsIn the obese population, there were strong correlation between fat distribution in central region and comorbidity, which was affected by sex, age, number of comorbidities, and type of comorbidity.
Keywords