Endothelial Cell Dynamics in Vascular Development: Insights From Live-Imaging in Zebrafish

Kazuhide S. Okuda; Kazuhide S. Okuda; Benjamin M. Hogan; Benjamin M. Hogan; Benjamin M. Hogan

doi:10.3389/fphys.2020.00842

Frontiers in Physiology (Jul 2020)

Endothelial Cell Dynamics in Vascular Development: Insights From Live-Imaging in Zebrafish

Kazuhide S. Okuda,
Kazuhide S. Okuda,
Benjamin M. Hogan,
Benjamin M. Hogan,
Benjamin M. Hogan

Affiliations

Kazuhide S. Okuda: Organogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
Kazuhide S. Okuda: Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia
Benjamin M. Hogan: Organogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia
Benjamin M. Hogan: Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia
Benjamin M. Hogan: Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, VIC, Australia

DOI: https://doi.org/10.3389/fphys.2020.00842
Journal volume & issue: Vol. 11

Abstract

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The formation of the vertebrate vasculature involves the acquisition of endothelial cell identities, sprouting, migration, remodeling and maturation of functional vessel networks. To understand the cellular and molecular processes that drive vascular development, live-imaging of dynamic cellular events in the zebrafish embryo have proven highly informative. This review focusses on recent advances, new tools and new insights from imaging studies in vascular cell biology using zebrafish as a model system.

Published in Frontiers in Physiology

ISSN: 1664-042X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Physiology
Website: https://www.frontiersin.org/journals/physiology

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