Schizophrenia (Mar 2025)
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
- Kelly Allott,
- Walid Yassin,
- Luis Alameda,
- Tashrif Billah,
- Owen Borders,
- Kate Buccilli,
- Ricardo E. Carrión,
- Rolando I. Castillo-Passi,
- Kang Ik K. Cho,
- Kota Chin,
- Michael J. Coleman,
- Beau-Luke Colton,
- Sebastián Corral,
- Dominic Dwyer,
- Kristina Ballestad Gundersen,
- Ruben C. Gur,
- Gil D. Hoftman,
- Grace R. Jacobs,
- Sinead Kelly,
- Kathryn E. Lewandowski,
- Patricia J. Marcy,
- Priya Matneja,
- Danielle McLaughlin,
- Angela R. Nunez,
- Setari Parsa,
- Nora Penzel,
- Susan Ray,
- Jenna M. Reinen,
- Kosha Ruparel,
- Michael S. Sand,
- Gennarina Santorelli,
- Johanna Seitz-Holland,
- Jessica Spark,
- Zailyn Tamayo,
- Andrew Thompson,
- Sophie Tod,
- Cassandra M. J. Wannan,
- Alana Wickham,
- Stephen J. Wood,
- Eirini Zoupou,
- Jean Addington,
- Alan Anticevic,
- Celso Arango,
- Nicholas J. K. Breitborde,
- Matthew R. Broome,
- Kristin S. Cadenhead,
- Monica E. Calkins,
- Eric Yu Hai Chen,
- Jimmy Choi,
- Philippe Conus,
- Cheryl M. Corcoran,
- Barbara A. Cornblatt,
- Lauren M. Ellman,
- Paolo Fusar-Poli,
- Pablo A. Gaspar,
- Carla Gerber,
- Louise Birkedal Glenthøj,
- Leslie E. Horton,
- Christy Lai Ming Hui,
- Joseph Kambeitz,
- Lana Kambeitz-Ilankovic,
- Matcheri Keshavan,
- Sung-Wan Kim,
- Nikolaos Koutsouleris,
- Jun Soo Kwon,
- Kerstin Langbein,
- Daniel Mamah,
- Covadonga M. Diaz-Caneja,
- Daniel H. Mathalon,
- Vijay A. Mittal,
- Merete Nordentoft,
- Godfrey D. Pearlson,
- Diana O. Perkins,
- Jesus Perez,
- Albert R. Powers,
- Jack Rogers,
- Fred W. Sabb,
- Jason Schiffman,
- Jai L. Shah,
- Steven M. Silverstein,
- Stefan Smesny,
- Gregory P. Strauss,
- Judy L. Thompson,
- Rachel Upthegrove,
- Swapna K. Verma,
- Jijun Wang,
- Daniel H. Wolf,
- Ofer Pasternak,
- Sylvain Bouix,
- Patrick D. McGorry,
- John M. Kane,
- Rene S. Kahn,
- Carrie E. Bearden,
- Martha E. Shenton,
- Scott W. Woods,
- Barnaby Nelson,
- Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ),
- William S. Stone
Affiliations
- Kelly Allott
- Orygen
- Walid Yassin
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School
- Luis Alameda
- General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of Lausanne
- Tashrif Billah
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Owen Borders
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Kate Buccilli
- Orygen
- Ricardo E. Carrión
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine
- Rolando I. Castillo-Passi
- Department of Psychiatry, IMHAY, University of Chile
- Kang Ik K. Cho
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Kota Chin
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Michael J. Coleman
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Beau-Luke Colton
- Orygen
- Sebastián Corral
- Department of Psychiatry, University of Chile
- Dominic Dwyer
- Orygen
- Kristina Ballestad Gundersen
- VIRTU Research Group, Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen
- Ruben C. Gur
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Gil D. Hoftman
- Northwell Health
- Grace R. Jacobs
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Sinead Kelly
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Kathryn E. Lewandowski
- Psychotic Disorders Division, McLean Hospital
- Patricia J. Marcy
- Northwell Health
- Priya Matneja
- Northwell Health
- Danielle McLaughlin
- Northwell Health
- Angela R. Nunez
- Department of Psychiatry, Yale University School of Medicine
- Setari Parsa
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School
- Nora Penzel
- Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School
- Susan Ray
- Northwell Health
- Jenna M. Reinen
- IBM Research
- Kosha Ruparel
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Michael S. Sand
- S2 Consulting LLC
- Gennarina Santorelli
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School
- Johanna Seitz-Holland
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Jessica Spark
- Orygen
- Zailyn Tamayo
- Department of Psychiatry, Yale University School of Medicine
- Andrew Thompson
- Orygen
- Sophie Tod
- Orygen
- Cassandra M. J. Wannan
- Orygen
- Alana Wickham
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Stephen J. Wood
- Orygen
- Eirini Zoupou
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Jean Addington
- Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary
- Alan Anticevic
- Department of Psychiatry, Yale University School of Medicine
- Celso Arango
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense
- Nicholas J. K. Breitborde
- Department of Psychiatry and Behavioral Health, Ohio State University
- Matthew R. Broome
- Institute for Mental Health, School of Psychology, University of Birmingham
- Kristin S. Cadenhead
- University of California
- Monica E. Calkins
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Eric Yu Hai Chen
- Department of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong
- Jimmy Choi
- Olin Neuropsychiatry Research Center, Hartford Health Care Behavioral Health Network
- Philippe Conus
- General Psychiatry Service, Treatment and Early Intervention in Psychosis Program (TIPP–Lausanne), Lausanne University Hospital and University of Lausanne
- Cheryl M. Corcoran
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Barbara A. Cornblatt
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine
- Lauren M. Ellman
- Department of Psychology & Neuroscience, Temple University
- Paolo Fusar-Poli
- Department of Psychosis Studies, King’s College London
- Pablo A. Gaspar
- Institute of Behavioral Science, Feinstein Institute for Medical Research
- Carla Gerber
- Prevention Science Institute, University of Oregon
- Louise Birkedal Glenthøj
- VIRTU Research Group, Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen
- Leslie E. Horton
- Department of Psychiatry, University of Pittsburgh School of Medicine
- Christy Lai Ming Hui
- Department of Psychiatry, School of Clinical Medicine, LKF Faculty of Medicine, University of Hong Kong
- Joseph Kambeitz
- University of Cologne, Faculty of Medicine and University HospitalCologne
- Lana Kambeitz-Ilankovic
- University of Cologne, Faculty of Medicine and University HospitalCologne
- Matcheri Keshavan
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School
- Sung-Wan Kim
- Department of Psychiatry, Chonnam National University Medical School
- Nikolaos Koutsouleris
- Department of Psychosis Studies, King’s College London
- Jun Soo Kwon
- Department of Psychiatry, Seoul National University College of Medicine
- Kerstin Langbein
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Daniel Mamah
- Department of Psychiatry, Washington University School of Medicine
- Covadonga M. Diaz-Caneja
- Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, ISCIII, School of Medicine, Universidad Complutense
- Daniel H. Mathalon
- Department of Psychiatry and Behavioral Sciences and Weill Institute for Neurosciences, University of California, San Francisco
- Vijay A. Mittal
- Department of Psychology, Northwestern University
- Merete Nordentoft
- Copenhagen Research Centre for Mental Health, Mental Health Copenhagen, University of Copenhagen
- Godfrey D. Pearlson
- Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital
- Diana O. Perkins
- Department of Psychiatry, University of North Carolina
- Jesus Perez
- CAMEO, Early Intervention in Psychosis Service, Cambridgeshire and Peterborough NHS Foundation Trust
- Albert R. Powers
- Connecticut Mental Health Center
- Jack Rogers
- Institute for Mental Health, School of Psychology, University of Birmingham
- Fred W. Sabb
- Prevention Science Institute, University of Oregon
- Jason Schiffman
- Department of Psychological Science, University of California
- Jai L. Shah
- PEPP-Montreal, Douglas Research Centre
- Steven M. Silverstein
- Department of Psychiatry, University of Rochester Medical Center
- Stefan Smesny
- Department of Psychiatry and Psychotherapy, Jena University Hospital
- Gregory P. Strauss
- Department of Psychology, University of Georgia
- Judy L. Thompson
- Department of Psychiatry, University of Rochester Medical Center
- Rachel Upthegrove
- Institute for Mental Health, School of Psychology, University of Birmingham
- Swapna K. Verma
- Institute of Mental Health
- Jijun Wang
- Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine
- Daniel H. Wolf
- Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania
- Ofer Pasternak
- Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School
- Sylvain Bouix
- Department of Software Engineering and Information Technology, Ecole de technologie superieure
- Patrick D. McGorry
- Orygen
- John M. Kane
- Department of Psychiatry, Donald and Barbara Zucker School of Medicine
- Rene S. Kahn
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Carrie E. Bearden
- Departments of Psychiatry and Biobehavioral Sciences & Psychology, Semel Institute for Neuroscience and Human Behavior, University of California
- Martha E. Shenton
- Departments of Psychiatry and Radiology, Brigham and Women’s Hospital, and Massachusetts General Hospital, Harvard Medical School
- Scott W. Woods
- Connecticut Mental Health Center
- Barnaby Nelson
- Orygen
- Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
- William S. Stone
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Massachusetts Mental Health Center and Harvard Medical School
- DOI
- https://doi.org/10.1038/s41537-025-00578-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Abstract Cognitive impairment occurs at higher rates in individuals at clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance to multivariate prediction models of transition to psychosis. Such impairment is considered a core biomarker of schizophrenia. Thus, cognition is a key domain measured in the Accelerating Medicines Partnership® program for Schizophrenia (AMP SCZ initiative). The aim of this paper is to describe the rationale, processes, considerations, and final harmonization of the cognitive battery used in AMP SCZ across the two data collection networks. This battery comprises tests of general intellect and specific cognitive domains. We estimate premorbid intelligence at baseline and measure current intelligence at baseline and 2 years. Eight tests from the Penn Computerized Neurocognitive Battery (PennCNB), which measure verbal learning and memory, sensorimotor ability, attention, emotion recognition, working memory, processing speed, verbal memory, visual memory, and motor speed are administered repeatedly at baseline, and four follow-up timepoints over 2 years. Watch Dr. Kelly Allott and Dr. William S. Stone discuss their work and this article: https://vimeo.com/1023396087 .
